Synthesis, X-Ray Crystal Structures, and Preliminary Antiproliferative Activities of New s-Triazine-hydroxybenzylidene Hydrazone Derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis, crystal structures and spectroscopic properties of triazine-based hydrazone derivatives; a comparative experimental-theoretical study.
We report here a comparative theoretical and experimental study of four triazine-based hydrazone derivatives. The hydrazones are synthesized by a three step process from commercially available benzil and thiosemicarbazide. The structures of all compounds were determined by using the UV-Vis., FT-IR, NMR (1H and 13C) spectroscopic techniques and finally confirmed unequivocally by single crystal X...
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Both sonochemical and classical methodologies have been employed to convert camphor, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one, C₉H16C=O, into a number of derivatives including hydrazones, C₉H16C=N-NHAr 3, imines, C₉H16C=N-R 7, and the key intermediate nitroimine, C₉H16C=N-NO₂ 6. Reactions of nitroamine 6 with nucleophiles by classical methods provided the desired compounds in a range of yields...
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There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Th...
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To make low-cost catalytic materials that mimic the activity of tyrosinase enzymes 29 (Catechol oxidase) is an exciting challenge of biochemical technology. Herein, we report the 30 synthesis of a series of acylhydrazone-pyrazoles based biomolecule materials (L1-L7) with superior 31 catecholase activity. These biomolecules were synthesized by a one pot chemical condensation 32 between 5-methyl-...
متن کاملSynthesis, In-silico Studies, of New Substituted Pyrazolone Based Hydrazone Derivatives and Their Biological Activities
In silico studies have been helpful in identifying the potential lead molecules with reduced cost. The title compounds were synthesized successfully by the reported method and the structures were confirmed on the basis of results of different spectral data. The in silico studies were carried out to find the possibility of the proposed activity using different software’s. Molinspiration, Osiris ...
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ژورنال
عنوان ژورنال: Journal of Chemistry
سال: 2019
ISSN: 2090-9063,2090-9071
DOI: 10.1155/2019/9403908